What is diabetes?
Diabetes is a big disease in which blood glucose levels are above normal. People with diabetes have problems converting food to energy. After a meal, food is broken down into a sugar called glucose, which is carried by the blood to cells throughout the body. Cells use insulin, a hormone made in the pancreas, to help them convert blood glucose into energy.People develop diabetes because the pancreas does not make enough insulin or because the cells in the muscles, liver, and fat do not use insulin properly, or both. As a result, the amount of glucose in the blood increases while the cells are starved of energy. Over the years, high blood glucose, also called hyperglycemia, damages nerves and blood vessels, which can lead to complications such as heart disease and stroke, kidney disease, blindness, nerve problems, gum infections, and amputation.
Types of Diabetes
The three main types of diabetes are type 1, type 2, and gestational diabetes.
- Type 1 diabetes, formerly called juvenile diabetes, is usually first diagnosed in children, teenagers, or young adults. In this form of diabetes, the beta cells of the pancreas no longer make insulin because the body's immune system has attacked and destroyed them.
- Type 2 diabetes, formerly called adult-onset diabetes, is the most common form. People can develop it at any age, even during childhood. This form of diabetes usually begins with insulin resistance, a condition in which muscle, liver, and fat cells do not use insulin properly. At first, the pancreas keeps up with the added demand by producing more insulin. In time, however, it loses the ability to secrete enough insulin in response to meals.
- Gestational diabetes develops in some women during the late stages of pregnancy. Although this form of diabetes usually goes away after the baby is born, a woman who has had it is more likely to develop type 2 diabetes later in life. Gestational diabetes is caused by the hormones of pregnancy or by a shortage of insulin.
Type 1 Diabetes and Type 2 Diabetes
To move away from basing the names of the two main types of diabetes
on treatment or age at onset, an American Diabetes Association expert
committee recommended in 1997 universal adoption of simplified
terminology. The National Institute of Diabetes and Digestive and Kidney
Diseases (NIDDK) agrees.
Former Names
|
Preferred Names |
---|---|
Type I juvenile diabetes insulin-dependent diabetes mellitus IDDM |
type 1 diabetes |
Type II adult-onset diabetes noninsulin-dependent diabetes mellitus NIDDM |
type 2 diabetes |
What is pre-diabetes?
In pre-diabetes, blood glucose levels are higher than normal but not
high enough to be characterized as diabetes. However, many people with
pre-diabetes develop type 2 diabetes within 10 years. Pre-diabetes also
increases the risk of heart disease and stroke. With modest weight loss
and moderate physical activity, people with pre-diabetes can delay or
prevent type 2 diabetes.
How are diabetes and pre-diabetes diagnosed?
The following tests are used for diagnosis:
- A fasting plasma glucose test measures your blood glucose after you have gone at least 8 hours without eating. This test is used to detect diabetes or pre-diabetes.
- An oral glucose tolerance test measures your blood glucose after you have gone at least 8 hours without eating and 2 hours after you drink a glucose-containing beverage. This test can be used to diagnose diabetes or pre-diabetes.
- In a random plasma glucose test, your doctor checks your blood glucose without regard to when you ate your last meal. This test, along with an assessment of symptoms, is used to diagnose diabetes but not pre-diabetes.
Positive test results should be confirmed by repeating the fasting
plasma glucose test or the oral glucose tolerance test on a different
day.
Fasting Plasma Glucose (FPG) Test
The FPG is the preferred test for diagnosing diabetes due to
convenience and is most reliable when done in the morning. Results and
their meaning are shown in table 1. If your fasting glucose level is 100
to 125 mg/dL, you have a form of pre-diabetes called impaired fasting
glucose (IFG), meaning that you are more likely to develop type 2
diabetes but do not have it yet. A level of 126 mg/dL or above,
confirmed by repeating the test on another day, means that you have
diabetes.
Table 1. Fasting Plasma Glucose Test
Plasma Glucose Result (mg/dL)
|
Diagnosis
|
---|---|
99 and below | Normal |
100 to 125 | Pre-diabetes (impaired fasting glucose) |
126 and above | Diabetes* |
*Confirmed by repeating the test on a different day.
Oral Glucose Tolerance Test (OGTT)
Research has shown that the OGTT is more sensitive than the FPG test
for diagnosing pre-diabetes, but it is less convenient to administer.
The OGTT requires you to fast for at least 8 hours before the test. Your
plasma glucose is measured immediately before and 2 hours after you
drink a liquid containing 75 grams of glucose dissolved in water. If
your blood glucose level is between 140 and 199 mg/dL 2 hours after
drinking the liquid, you have a form of pre-diabetes called impaired
glucose tolerance or IGT, meaning that you are more likely to develop
type 2 diabetes but do not have it yet. A 2-hour glucose level of 200
mg/dL or above, confirmed by repeating the test on another day, means
that you have diabetes.
2-Hour Plasma Glucose Result (mg/dL) | Diagnosis |
---|---|
139 and below | Normal |
140 to 199 | Pre-diabetes (impaired glucose tolerance) |
200 and above | Diabetes* |
*Confirmed by repeating the test on a different day.
Gestational diabetes is also diagnosed based on plasma glucose values
measured during the OGTT. Blood glucose levels are checked four times
during the test. If your blood glucose levels are above normal at least
twice during the test, you have gestational diabetes. Table 3 shows the above-normal results for the OGTT for gestational diabetes.
Table 3. Gestational Diabetes: Above-Normal
Results for the Oral Glucose Tolerance Test
When | Plasma Glucose Result (mg/dL) |
---|---|
Fasting | 95 or higher |
At 1 hour | 180 or higher |
At 2 hours | 155 or higher |
At 3 hours | 140 or higher |
Note: Some laboratories use other numbers for this test.
Random Plasma Glucose Test
A random blood glucose level of 200 mg/dL or more, plus presence of the following symptoms, can mean that you have diabetes:
- increased urination
- increased thirst
- unexplained weight loss
Other symptoms include fatigue, blurred vision, increased hunger, and
sores that do not heal. Your doctor will check your blood glucose level
on another day using the FPG or the OGTT to confirm the diagnosis.
Diabetes Aaurveda Treatment
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